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apalutamide will decrease the extent or outcome of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication that happen to be CYP3A4 substrates may result in decrease exposure to these medicines.This medication might cau